Baby Aspirin Recalled After Acetaminophen Discovery

More than 16,000 bottles of baby aspirin are being recalled by Advance Pharmaceutical Inc. after one of the bottles was found to be filled with acetaminophen pills.

The recall covers 120-pill bottles labeled to contain 81-milligram aspirin pills. The bottle discovered by a CVS pharmacist contained 500-mg acetaminophen pills, ABC News reported.

No injuries have been reported, according to Advance Pharmaceutical spokesman Abu Amanatullah.

Doctors said that unknowningly taking acetaminophen instead of baby aspirin could lead to an overdose that results in liver failure, the need for a liver transplant or death, ABC News reported.

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Aspirin Equals Pricier Blood Thinner for Preventing Clots: Study

After hip replacement, no disadvantage found for the low-cost treatment

By Serena Gordon

HealthDay Reporter

TUESDAY, June 4 (HealthDay News) -- Aspirin appears to be just as good as more expensive, more potent blood-thinning medication for preventing blood clots after hip replacement surgery, according to new research.

People who get artificial hips are at risk of serious blood clots, such as deep vein thrombosis and pulmonary embolism, after the surgery. To prevent them, doctors usually prescribe blood-thinning (anticoagulant) medications, such as low-molecular-weight heparin, which is given by injection, or the newer drug, rivaroxaban (brand name Xarelto), a pill.

But that old medicine-cabinet standby, aspirin, also has blood-thinning properties. And the Canadian researchers wondered if this simple, inexpensive drug could also prevent blood clots after a major surgery.

They compared the drugs for four weeks, following 10 days of treatment with heparin immediately post-surgery.

The investigators found the two medications were similarly effective and safe. Where the medicines differ significantly is in cost.

"Low-molecular-weight heparin and the newer blood thinner, Xarelto, are similarly priced; they're several hundred-fold more expensive than aspirin," said the study's lead author, Dr. David Anderson, a professor and head of the department of medicine at Dalhousie University in Halifax, Nova Scotia.

"Given the low cost of aspirin and its convenience, it's a reasonable alternative to low-molecular-weight heparin when used in the manner designed in this trial," said Anderson.

Another expert said the study results, published in the June 4 issue of the Annals of Internal Medicine, support previous observations. "After initial treatment with an anticoagulant, then giving aspirin to these patients for the prevention of [serious blood clots] is as good," said Jawed Fareed, professor of pharmacology and pathology and director of the hemostasis and thrombosis research unit at Loyola University Medical Center in Maywood, Ill.

For the study, Anderson and his colleagues recruited 778 patients undergoing elective hip replacement surgery between 2007 and 2010. All received 10 days of heparin (dalteparin) following surgery. After that, they were randomized into one of two groups for four more weeks of blood-thinning therapy. Half continued receiving heparin injections, while the other half took low-dose (81 milligrams) aspirin daily.

Five people on dalteparin and one on aspirin developed a blood clot. The absolute difference between the two therapies was 1 percent. Bleeding events serious enough to require treatment occurred in five people on dalteparin, and two on aspirin.

Anderson said the difference in bleeding events wasn't statistically significant, but there was a trend toward aspirin being the safer alternative. However, it's too soon to tell definitively whether aspirin might cause less bleeding, he said.

Anderson said the researchers had to stop the study early because they weren't able to recruit the desired number of patients. While the study was under way, Xarelto was approved, and because it's a pill instead of an injectable like dalteparin (brand name Fragmin), it became difficult to find volunteers for the multiple injection part of the trial.

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Daily Aspirin Linked to Lower Risk for Deadly Skin Cancer in Women

Title: Daily Aspirin Linked to Lower Risk for Deadly Skin Cancer in Women
Category: Health News
Created: 3/11/2013 10:35:00 AM
Last Editorial Review: 3/11/2013 12:00:00 AM

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Daily Aspirin Linked to Lower Risk for Deadly Skin Cancer in Women

Large study found up to 30 percent reduced odds of developing melanoma

By Steven Reinberg

HealthDay Reporter

MONDAY, March 11 (HealthDay News) -- Older women who take an aspirin regularly may be lowering their risk of developing the deadly skin cancer melanoma, a new study suggests.

And the longer postmenopausal women take aspirin, the more melanoma risk appears to diminish.

The effect is only seen with aspirin, not with other pain relievers such as acetaminophen (Tylenol), the researchers noted.

For the study, the research team collected data on nearly 60,000 white women who were part of the Women's Health Initiative, a long-term national study. The women, aged between 50 and 79, were asked about what medications they took and other lifestyle preferences.

Over 12 years of follow-up, the investigators found that women who took aspirin had a 21 percent lower risk of developing melanoma compared to women who didn't take aspirin.

But it's too soon to make firm conclusions, a researcher cautioned.

"Aspirin could be potentially used to prevent melanoma, but a clinical trial is needed," said lead author Dr. Jean Tang, an assistant professor of dermatology at Stanford University School of Medicine in Palo Alto, Calif.

This type of population-based study can only show an association between aspirin and the reduced risk for melanoma, not that aspirin actually helps prevent it.

Tang doesn't believe women should start taking aspirin solely to try to prevent melanoma. "It's too early to say this," she said.

It is possible that aspirin's anti-inflammatory properties might be responsible for lowering the risk of melanoma, Tang suggested. "Aspirin may also promote cell death of melanoma cells," she added.

Whether a protective effect also occurs in men is not known, said Tang, who plans to look at that in her next study.

The new report was published in the March 11 online edition of Cancer.

The study found that women who took aspirin for at least five years had their melanoma risk drop by 30 percent, compared to women who didn't take aspirin.

To try to isolate the effect of aspirin on melanoma, Tang's group accounted for other factors such as skin tone, tanning and use of sunscreen.

Each year in the United States there are nearly 77,000 new cases of melanoma and more than 9,000 deaths from it, according to the U.S. National Cancer Institute.

One expert doesn't see any problem taking aspirin to prevent melanoma, especially for people with a family history of the disease.

Prolonged use of aspirin is not without risks, including stomach bleeding, but the benefits of preventing melanoma outweigh the risk for vulnerable people, said Dr. Michele Green, a dermatologist at Lenox Hill Hospital in New York City. She praised the new research.

"I think it's fantastic. It's really a remarkable study," Green said.

"If you have a family history of melanoma, I don't see any downside of taking aspirin for this," she said. "I would urge my patients who have a family history of melanoma to take aspirin based on this study."

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Skipping Aspirin Before Artery Procedure May Boost Death Rates

Title: Skipping Aspirin Before Artery Procedure May Boost Death Rates
Category: Health News
Created: 3/7/2013 12:36:00 PM
Last Editorial Review: 3/8/2013 12:00:00 AM

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Aspirin Linked to Blinding Eye Disease

Jan. 22, 2013 -- Regular aspirin users are more likely to develop the “wet” form of age-related macular degeneration compared to people who rarely or never take the drug, a new study shows.

Aspirin is one of the most widely used drugs in the world. Millions of people with heart disease take a daily low dose of aspirin in hopes of preventing heart attacks and stroke. It’s also used to ease pain.

Macular degeneration is a leading cause of blindness in older adults, and it is on the rise. The “wet” form accounts for only about 10% to 15% of cases, but it progresses more rapidly and is more likely to lead to vision loss than the “dry” form.

In “wet” macular degeneration, tiny new blood vessels grow under the retina, the light-sensing part of the eye. These blood vessels break open and leak, causing scar tissue to form. Over time, the scar tissue clouds central vision. It’s not clear why this happens.

Both kinds of macular degeneration become more common as people age. Beyond age, the only risk factor that’s consistently been linked to the condition is smoking.

News that aspirin may be linked to macular degeneration surfaced last year when a large European study found that regular aspirin users were more likely to develop the sight-stealing disease. Before that, two large studies found no association between aspirin and macular degeneration. Another study had even suggested that aspirin might protect against the “dry” form of the disease.

For the new study, researchers in Australia followed more than 2,000 older adults. Doctors conducted detailed interviews at the start of the study, asking people about a variety of diet and lifestyle habits, including medication use. About 11% of people (257) were regular aspirin users, meaning they'd taken the drug at least once a week in the past year.

Study participants had regular eye exams to check for changes to their retinas.

Fifteen years later, 63 people in the study -- 15 regular aspirin users and 48 who rarely or never took it -- had developed “wet” macular degeneration.

Compared to people who never took aspirin, regular users were more than twice as likely to develop macular degeneration. That was true even after researchers accounted for other things known to influence a person’s risk for macular degeneration, including age, sex, smoking, heart disease, BMI, and high blood pressure.

The findings are published in the journal JAMA Internal Medicine.

The study doesn’t prove that aspirin causes macular degeneration. Different kinds of studies are needed to understand whether aspirin may directly harm the eye. 

But one theory is that aspirin ramps up a part of the immune system called the complement system. Many people with macular degeneration carry a form of a gene that keeps them from being able to turn down the complement system when needed. Researchers say the result is that the immune system may be chronically overstimulated, causing damage to the back of the eye.

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Regular Aspirin Use May Boost Eye Problem Risk

Dec. 18, 2012 -- Taking aspirin regularly appears to slightly raise the risk of the eye condition known as age-related macular degeneration or AMD, new research suggests.

The increased risk only occurred with people who had taken aspirin regularly 10 years before they were diagnosed with the potentially blinding eye disease. They had taken aspirin at least twice a week for more than three months, says researcher Barbara E.K. Klein, MD, MPH.

The risk was for the type of macular degeneration known as wet or neovascular AMD, says Klein, professor of ophthalmology and visual sciences at the University of Wisconsin School of Medicine, Madison.

Wet macular degeneration is generally more severe than another version, known as dry macular degeneration.

Although people taking aspirin regularly were two times more likely to get the condition, Klein says the absolute risk is still low because the condition is not common. About 1% of people aged mid-40s and older get wet macular degeneration, she says.

Klein studied nearly 5,000 men and women, ages 43 and older. She followed them for 20 years, although not all of them stayed in the study that long.

The research is published in the Journal of the American Medical Association.

Previous research findings about aspirin use and macular degeneration risk have been mixed.

As aspirin use and macular degeneration are increasing, Klein decided to follow men and women over many years to see if she could find a link.

Nearly 20% of adults, or 1 in 5, take aspirin regularly. Some use it for temporary relief of pain or fever. Others take it daily to prevent heart attacks.

The macula is a small area of the retina, the tissue lining the back of the eye, that is responsible for central vision.

Klein looked at wet (late) and dry (early) macular degeneration for the study. Both are potentially blinding conditions.

Over the course of the study, 512 people were diagnosed with early AMD and 117 with late AMD.

Although regular use of aspirin 10 years before the diagnosis was linked with late macular degeneration, aspirin use five years before the diagnosis was not linked with an increased risk of either form of AMD.

Klein can't explain the link and says it requires more study. "The absolute risk of this is small," she says. "There are so many folks who have been put on aspirin for [heart disease] prevention. ... The [heart] protective effect is still primo."

One co-author, Ronald Klein, MD, MPH, has served as a consultant for Pfizer, which makes AMD medicine. The study was funded by the National Institutes of Health and support from Research to Prevent Blindness.

"This study is suggestive that there may be a relationship but it is by no means definitive," says George Williams, MD, professor and chair of the department of ophthalmology at Oakland University's William Beaumont School of Medicine in Rochester, Mich.

Williams says a weakness in the study is that the men and women self-reported the aspirin use, so it may not have been totally accurate.

If a cardiologist has recommended aspirin for heart disease protection, Williams says, "I would not take anyone off it."

People who take aspirin regularly should consider their risk of macular degeneration and the benefits of taking aspirin, says Michael Tolentino, MD, medical director of the Macular Degeneration Association and an ophthalmologist in Lakeland, Fla.

People at higher risk for the disease include those with a family history, those with light eyes, and smokers.

"Everything is a risk-benefit ratio," he says.

He reports serving as consultant for Novartis, Genentech, Alarcon, and other companies involved in eye drugs.

View the original article here

Regular Aspirin Use May Boost Eye Problem Risk

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WebMD Health News Reviewed byLaura J. Martin, MD

Dec. 18, 2012 -- Taking aspirin regularly appears to slightly raise the risk of the eye condition known as age-related macular degeneration or AMD, new research suggests.

The increased risk only occurred with people who had taken aspirin regularly 10 years before they were diagnosed with the potentially blinding eye disease. They had taken aspirin at least twice a week for more than three months, says researcher Barbara E.K. Klein, MD, MPH.

The risk was for the type of macular degeneration known as wet or neovascular AMD, says Klein, professor of ophthalmology and visual sciences at the University of Wisconsin School of Medicine, Madison.

Wet macular degeneration is generally more severe than another version, known as dry macular degeneration.

Although people taking aspirin regularly were two times more likely to get the condition, Klein says the absolute risk is still low because the condition is not common. About 1% of people aged mid-40s and older get wet macular degeneration, she says.

Klein studied nearly 5,000 men and women, ages 43 and older. She followed them for 20 years, although not all of them stayed in the study that long.

The research is published in the Journal of the American Medical Association.

Aspirin & Eye Problems: Study Details

Previous research findings about aspirin use and macular degeneration risk have been mixed.

As aspirin use and macular degeneration are increasing, Klein decided to follow men and women over many years to see if she could find a link.

Nearly 20% of adults, or 1 in 5, take aspirin regularly. Some use it for temporary relief of pain or fever. Others take it daily to prevent heart attacks.

The macula is a small area of the retina, the tissue lining the back of the eye, that is responsible for central vision.

Klein looked at wet (late) and dry (early) macular degeneration for the study. Both are potentially blinding conditions.

Over the course of the study, 512 people were diagnosed with early AMD and 117 with late AMD.

Although regular use of aspirin 10 years before the diagnosis was linked with late macular degeneration, aspirin use five years before the diagnosis was not linked with an increased risk of either form of AMD.

Klein can't explain the link and says it requires more study. "The absolute risk of this is small," she says. "There are so many folks who have been put on aspirin for [heart disease] prevention. ... The [heart] protective effect is still primo."

One co-author, Ronald Klein, MD, MPH, has served as a consultant for Pfizer, which makes AMD medicine. The study was funded by the National Institutes of Health and support from Research to Prevent Blindness.

Aspirin & Eye Problems: Perspective

"This study is suggestive that there may be a relationship but it is by no means definitive," says George Williams, MD, professor and chair of the department of ophthalmology at Oakland University's William Beaumont School of Medicine in Rochester, Mich.

Williams says a weakness in the study is that the men and women self-reported the aspirin use, so it may not have been totally accurate.

If a cardiologist has recommended aspirin for heart disease protection, Williams says, "I would not take anyone off it."

People who take aspirin regularly should consider their risk of macular degeneration and the benefits of taking aspirin, says Michael Tolentino, MD, medical director of the Macular Degeneration Association and an ophthalmologist in Lakeland, Fla.

People at higher risk for the disease include those with a family history, those with light eyes, and smokers.

"Everything is a risk-benefit ratio," he says.

He reports serving as consultant for Novartis, Genentech, Alarcon, and other companies involved in eye drugs.

View Article Sources

SOURCES:

Klein, B. Journal of the American Medical Association, Dec. 19, 2012.

Barbara E.K. Klein, MD, MPH, professor of ophthalmology and visual sciences, University of Wisconsin School of Medicine, Madison.

George Williams, MD, spokesman, American Academy of Ophthalmology; professor and chair of ophthalmology, Oakland University William Beaumont School of Medicine, Rochester, Mich.

Michael Tolentino, MD, medical director, Macular Degeneration Association; associate professor of ophthalmology, University of Central Florida, Orlando; ophthalmologist, Lakeland, Fla.

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