Compound in Red Meat, Energy Drinks May Have Heart Disease Link

Gut bacteria break down carnitine into another substance that damages blood vessels, study finds

By Robert Preidt

HealthDay Reporter

SUNDAY, April 7 (HealthDay News) -- A compound found in red meat and added as a supplement to popular energy drinks promotes hardening and clogging of the arteries, otherwise known as atherosclerosis, a new study suggests.

Researchers say that bacteria in the digestive tract convert the compound, called carnitine, into trimethylamine-N-oxide (TMAO). Previous research by the same team of Cleveland Clinic investigators found that TMAO promotes atherosclerosis in people.

And there was an another twist: The study also found that a diet high in carnitine encourages the growth of the bacteria that metabolize the compound, leading to even higher TMAO production.

"The [type of] bacteria living in our digestive tracts are dictated by our long-term dietary patterns. A diet high in carnitine actually shifts our gut microbe composition to those that like carnitine, making meat eaters even more susceptible to forming TMAO and its artery-clogging effects," study leader Dr. Stanley Hazen, head of preventive cardiology and rehabilitation in Cleveland Clinic's Heart and Vascular Institute, said in a clinic news release.

Hazen's team looked at nearly 2,600 patients undergoing heart evaluations. The researchers found that consistently high carnitine levels were associated with a raised risk of heart disease, heart attack, stroke and heart-related death.

They also found that TMAO levels were much lower among vegetarians and vegans than among people with unrestricted diets (omnivores). Vegetarians do not eat meat while vegans do not eat any animal products, including eggs and dairy.

Even after consuming a large amount of carnitine, vegans and vegetarians did not produce significant levels of TMAO, while omnivores did, according to the study in the current issue of the journal Nature Medicine.

Although the new study could not prove any cause-and-effect relationship between carnitine and heart damage, the findings may provide a new understanding of the benefits of vegan and vegetarian diets, the researchers said.

"Vegans and vegetarians have a significantly reduced capacity to synthesize TMAO from carnitine, which may explain the cardiovascular health benefits of these diets," said Hazen, who is also vice chair of translational research for the clinic's Lerner Research Institute.

Two heart disease experts said the study yields up important new insights.

According to Dr. Robert Rosenson, it appears that poor eating habits could raise TMAO levels and "increase the ability of the cholesterol to get into our arteries and interfere with the ability of our body to eliminate that excess cholesterol." Rosenson, director of cardiometabolic disorders at the Icahn School of Medicine at Mount Sinai, in New York City, said the study "sheds important new information on the association between diet, atherosclerosis and cardiovascular events."

Another expert pointed the finger specifically at red meat and energy drinks.

"Most Americans have heard the famous saying 'you are what you eat,'" said Dr. Tara Narula, associate director of the Cardiac Care Unit at Lenox Hill Hospital, New York City. "This phrase may be more true and different than we might have imagined."

The new study "brings awareness that many 'supplements' like energy drinks can have the same [vessel-damaging] compounds as red meat," she said. "Energy drinks may not be harmless and can have unseen side effects that consumers should recognize."

As for beef, pork and the like, Narula said that the "real take-away message is the reinforcement of the current recommendations that a heart-healthy diet should have little to no red meat consumption."

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Energy Drinks Linked to Changes in Heart Rhythm

But more research is needed on the caffeine-laden beverages, review says

By Randy Dotinga

HealthDay Reporter

THURSDAY, March 21 (HealthDay News) -- Energy drinks boost blood pressure and may make the heart more susceptible to electrical short circuits, new research suggests.

But it's not clear how much of this effect on blood pressure has to do with caffeine, which also is found in coffee, or whether the effect significantly raises the risk of heart problems.

So should you put down your Red Bull or Monster Energy Drink? Not necessarily, experts say.

"I have no real concern that having an energy drink or two will negatively impact most people's health," said Dr. C. Michael White, a professor and head of pharmacy practice at the University of Connecticut. He has studied energy drinks and is familiar with the new review's findings.

However, he said, "there is enough information in this meta-analysis to make me concerned that there may be pockets of the population who may have an increased risk of adverse events, and more work needs to be done to see if this is true."

In other words, it's possible that some people could be especially vulnerable to the effects of energy drinks.

At issue are the caffeine-laden drinks that have become popular among people looking to stay alert, stay awake or get a jolt. Sixteen-ounce cans of drinks like Monster Energy Assault and Rockstar pack in about 160 milligrams of caffeine, compared with roughly 100 milligrams in a 6-ounce cup of coffee.

Energy drinks also come with other ingredients like sugar and herbs, and medical experts have warned that they can spell trouble.

Industry representatives defend energy drinks, saying they contain about as much caffeine by the ounce as coffeehouse drinks. But people often consume much more of the energy drinks at one time.

In the new report, researchers looked at seven studies. Among them, a total of 93 participants drank energy drinks and had their "QT interval" measured, while another 132 underwent blood pressure measurement. In most of the studies, the participants -- aged 18 to 45 -- drank one to three cans of Red Bull.

The QT interval is an electrocardiogram (EKG) measurement of how the heart resets itself electronically while it beats. A longer interval raises the risk that a "short circuit" will develop in the heart and possibly kill a person.

The review found that the QT intervals lengthened after people consumed energy drinks. Federal officials would raise an alarm if a medication produced this level of an effect, said review co-author Dr. Ian Riddock, a preventive cardiologist at the David Grant Medical Center at Travis Air Force Base, in California.

It's not known if the culprit is the caffeine or the other ingredients, "although we tend to think it's the latter," Riddock said.

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Sugary Drinks Tied to 25,000 U.S. Deaths a Year

Study estimated beverages' role in worldwide obesity and heart disease, diabetes, some cancers

By Amy Norton

HealthDay Reporter

TUESDAY, March 19 (HealthDay News) -- More than 180,000 deaths worldwide in 2010 were linked to a high intake of sugar-laden drinks, a new study estimates, including 25,000 deaths in the United States.

Most deaths occurred in middle- to low-income countries, the Harvard researchers noted.

The findings are surprising because "we often think of this as a problem only in high-income countries, like the U.S.," said lead researcher Gitanjali Singh, a research fellow at Harvard School of Public Health, in Boston.

She said her findings, presented Tuesday at an American Heart Association meeting in New Orleans, point to a need for policies that curb people's sugary drink intake.

One such effort, in New York City, is currently in the spotlight. Last week, a judge struck down Mayor Michael Bloomberg's controversial limit on large sweetened sodas and other sugary beverages, one day before the rule was to go into effect. Bloomberg said he would appeal the decision and defended his plan, which would have limited the size of sugary drinks sold at restaurants, food carts and theaters to 16 ounces.

Singh said that's not the only type of measure officials could take. Others could include taxing sugar-added drinks, or limiting advertising of the beverages to children.

But "anti-soda" moves are a tough sell -- not only because the beverage industry and many consumers resist. It's also hard to pin ill health effects on one component of people's diets, even if it's a nutritionally dubious one.

These latest findings do not prove that sugary drinks kill people. They only show a correlation between high consumption and deaths from heart disease, diabetes and certain cancers.

"This type of study cannot prove cause-and-effect," said Lona Sandon, an assistant professor of clinical nutrition at the University of Texas Southwestern Medical Center at Dallas.

"Sugary beverage consumption is often paired with other unhealthy food choices or behaviors," said Sandon, who was not involved in the study. "Chronic diseases, such as heart disease and diabetes, are the result of many factors, not just excess sugar intake."

That said, everyone should be limiting added sugar -- from drinks and food -- Sandon stressed. "We just do not need added sugar that is empty calories," she said.

The beverage industry also weighed in on the findings.

"This [study], which is neither peer-reviewed nor published, is more about sensationalism than science," the American Beverage Association (ABA) said in a statement issued Tuesday.

"In no way does it show that consuming sugar-sweetened beverages causes chronic diseases such as diabetes, cardiovascular disease or cancer -- the real causes of death among the studied subjects," the ABA added. "The researchers make a huge leap when they illogically and wrongly take beverage intake calculations from around the globe and allege that those beverages are the cause of deaths which the authors themselves acknowledge are due to chronic disease."

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healthy drinks any suggestions???

I have been getting tired of just drinking water and lemon water. I'm trying to cut out bad sugar and artificial sweeteners. What do you drink that is good for you that is not water??

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Diet Drinks As Mixers May Make for More Potent Cocktails

By Serena Gordon

HealthDay Reporter

TUESDAY, Feb. 5 (HealthDay News) -- Calorie counters, beware: Drinking diet "mixers" with alcohol intensifies the effects of the booze, according to the findings of breathalyzer tests.

Preliminary research on the use of different mixers, such as juice, soda or diet soda, suggests that diet soda might increase breath alcohol content more than higher calorie sugary beverages.

"The key thing is to be aware of this phenomenon," said study author Cecile Marczinski, an assistant professor in the department of psychological science at Northern Kentucky University in Highland Heights.

"People tend to think that cutting calories is important, but when you're drinking alcohol, calories help slow down the release of alcohol to your liver and brain," Marczinski said.

Breath alcohol concentration, which is what police measure to determine if someone has consumed more than the legal limit of alcohol, is affected by different factors. Food in the stomach can lower breath alcohol concentration by up to 57 percent compared to drinking on an empty stomach, according to background information in the study.

Because many people are concerned about their weight, particularly young women, the researchers wanted to see how a drink mixer might affect breath alcohol levels.

For the study, released Feb. 5 online in Alcoholism: Clinical and Experimental Research, the researchers recruited eight males and eight females, average age 23, to attend three study sessions. At one session, they drank vodka mixed with regular Squirt, a soda. At another, they drank vodka mixed with diet Squirt, which is artificially sweetened with aspartame. At the final session, a placebo session, they drank regular soda with a small amount of alcohol on the top of the drink to create the smell of booze.

At each session, the study volunteers drank the equivalent of three to four bar drinks in a short period of time, said Marczinski. Breath alcohol content was measured eight times in the three hours following the drinks' consumption.

Breath alcohol levels peaked 40 minutes after the study volunteers had their drinks. When the alcohol was mixed with regular soda containing sugar, the peak breath alcohol level was just under the legal limit at 0.077. But for diet soda drinkers, the peak was at 0.091, which is above the legal limit for driving a car.

Breath alcohol levels remained higher for the diet soda/alcohol drinkers for the entire three-hour period.

After drinking, the researchers also had the study volunteers perform a test on the computer. Participants who downed the diet drinks performed slightly worse, although they didn't notice any difference in the way they felt or performed.

"They were slower to respond. It was a small difference, but it was statistically significant," said Marczinski.

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Energy Drinks Pose Risks to Teens, Study Finds

By Randy Dotinga

HealthDay Reporter

FRIDAY, Feb. 1 (HealthDay News) -- A new report warns that popular energy drinks such as Red Bull and Rockstar pose potential hazards to teens, especially when mixed with alcohol.

The report, published in the February issue of the journal Pediatrics in Review, summarizes existing research and concludes that the caffeine-laden beverages can cause rapid heartbeat, high blood pressure, obesity and other medical problems in teens. Combined with alcohol, the potential harms can be severe, the authors noted.

"I don't think there is any sensationalism going on here. These drinks can be dangerous for teens," said review lead author Dr. Kwabena Blankson, a U.S. Air Force major and an adolescent medicine specialist at the Naval Medical Center in Portsmouth, Va. "They contain too much caffeine and other additives that we don't know enough about. Healthy eating, exercise and adequate sleep are better ways to get energy."

Doctors and parents need to "intelligently speak to teenagers about why energy drinks may not be safe," Blankson said. "They need to ask teens if they are drinking energy drinks and suggest healthy alternatives."

Surveys suggest that as many as half of young people consume these unregulated beverages, often in search of a hefty dose of caffeine to help them wake up, stay awake or get a "buzz."

Sixteen-ounce cans of Red Bull, Monster Energy Assault and Rockstar hold about 160 milligrams (mg) of caffeine, according to the report. However, a much smaller container of the drink Cocaine -- briefly banned in 2007 -- delivers 280 mg in just 8.4 ounces. By contrast, a typical cup of coffee packs a caffeine punch of about 100 mg.

Too much caffeine, Blankson said, "can have troubling side effects." More than 100 milligrams of caffeine a day is considered unhealthy for teens, he noted.

Energy drinks are often served cold and sometimes with ice, making them easier to chug than hot coffee. And many contain additives such as sugar, ginseng and guarana, which enhance the effect of caffeine, the researchers explained.

"We don't know what these additives do to the body after periods of extended use," Blankson said.

Moreover, young people often mix energy drinks and alcoholic beverages, or buy energy drinks that contain alcohol. One-quarter of students surveyed at 10 North Carolina universities said they had consumed energy drinks mixed with alcohol in the past month, the report noted. And 23 university students in New Jersey and nine in Washington state were hospitalized in 2010 after drinking an energy drink spiked with alcohol.

U.S. health officials have sounded alarms about energy drinks as well. The Substance Abuse and Mental Health Services Administration recently reported that hospital visits related to the drinks doubled, to almost 21,000, between 2007 and 2011. About 42 percent of cases also included drug or alcohol use, the agency said.

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Sweetened Drinks Linked to Depression Risk

Jan. 8, 2013 -- Drinking sweetened beverages -- either sugar-sweetened or diet -- may be linked with a slightly higher depression risk, while drinking coffee may slightly lower the risk.

That is the finding from a new study to be presented in March at the 65th annual meeting of the American Academy of Neurology in San Diego.

In the study, people who drank sweetened beverages -- including regular and diet sodas, fruit punch, and sweetened iced tea -- had a higher risk for depression.

Researchers say the findings suggest that cutting down on sweetened drinks or replacing them entirely with non-sweetened beverages may help lower depression risk.

But an expert who reviewed the findings says it failed to convince him that drinking sweetened beverages raises depression risk.

“There is much more evidence that people who are depressed crave sweet things than there is to suggest that sweetened beverages cause depression,” says neurologist Kenneth M. Heilman, MD.

Heilman is a professor of neurology at the University of Florida College of Medicine in Gainesville.

The study included close to 264,000 people over the age of 50 enrolled in an AARP diet and health study.

When they entered the study, the participants were asked about their beverage-drinking habits as part of a detailed dietary survey. About 10 years later they were asked if they had been diagnosed with depression over the previous decade.

The analysis revealed that people who drank more than four cans or cups of diet soda a day had about a 30% higher risk of developing depression over the follow-up period than those who drank none. Those who drank regular soda had a 22% higher risk.

Coffee drinking, however, was associated with a 10% reduction in depression risk.

Drinking diet sweetened-beverages appeared to be associated with a slightly higher depression risk overall than drinking sugar-sweetened beverages.

The researchers noted that more research is needed to confirm the findings. They warn that people with depression should continue to take all medications prescribed by their doctors.

“While our findings are preliminary, and the underlying biological mechanisms are not known, they are intriguing and consistent with a small but growing body of evidence suggesting that artificially sweetened beverages may be associated with poor health outcomes,” says researcher Honglei Chen, MD, PhD, of the National Institutes of Health in Research Triangle Park, N.C.

Heilman, who is a member of the American Academy of Neurology, says the fact that carbonated and non-carbonated sweetened beverages appeared to increase depression risk, as did drinks sweetened with sugar and non-calorie sweeteners, leads him to question the findings.

He notes that there is evidence to suggest that people who are depressed or have a higher risk for depression seek out sweet foods and drinks as a way of self-soothing.

“The main point is that you can never show cause and effect in a study like this one,” he says. “By telling people to cut down on sugar-sweetened drinks you may be reducing depression risk or having no impact or having the opposite effect and making depression worse.”

The study was supported by the Intramural Research Programs of the National Institutes of Health, the National Institute of Environmental Health Sciences, and the National Cancer Institute.

These findings will be presented at a medical conference. They should be considered preliminary as they have not yet undergone the "peer review" process, in which outside experts scrutinize the data prior to publication in a medical journal.

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Vitamin Drinks for Beautiful Skin – Do They Work?

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WebMD Feature Reviewed byEmmy M. Graber, MD

"Beauty beverages" have flooded the market in recent years, promising to transform humble water into a powerful anti-aging, skin perfecting potion.

According to market research firm Mintel, nearly 300 new food and drink products with "functional beauty benefits" launched in 2008, about double the number in 2007. Products like Borba, Glowelle, Crystal Light Skin Essentials, BeautyScoop, and Noah's Naturals Anti-Aging Beauty Elixir all claim to improve appearance and fight the signs of time on your skin.

But can what you drink really make a difference in how you look?

What Are Beauty Beverages?

"Just as beauty is in the eye of the beholder, a beauty drink is in the perspective of the consumer," says New York nutritionist Keri Glassman, MS, RD, CDN.

"Drinks with beauty benefits usually contain vitamins, amino acids, or botanicals that possess antioxidant activities," says New York dermatologist Francesca Fusco, MD. "A person should usually get enough of these nutrients through diet. But drinking them is a reasonable way to supplement."

How Well Do They Work?

There are nutrients that can improve skin health, but the jury is out on how effective a beauty beverage can be at shuttling this nutrition straight to your skin.

Ideally, everyone would eat a healthy diet packed with fruits and vegetables, lean protein, good fats, and whole grains, says Los Angeles dermatologist Howard Murad, MD, who sells supplements as part of his skincare line. He sees supplements as a good back-up plan.

"I have tried to put adequate amounts of supplements in drinks, but they aren't palatable at the levels required to see benefits," Murad says. "Plus, to make a supplement drinkable, you need to add preservatives, emulsifiers, and sweeteners -- things that aren't ideal to ingest."

The makers of beauty drinks say that sometimes eating well isn't enough. "Even people who eat a healthy diet have problems with their skin, hair, and nails," says plastic surgeon Michelle Yagoda, MD, creator of BeautyScoop. "So absorption can be a problem and liquids tend to be more bio-available to your body."

"A drinkable supplement can be an effective way to treat skin because it can contain vitamins that are more bio-available and easier for the body to absorb," says Scott-Vincent Borba, founder and CEO of the skin product company Borba.

However, experts such as New York dermatologist Neal Schultz, MD, disagree. "Certain nutrients do help the skin, but that doesn't mean putting them in a drink will have the same effect as eating a well-balanced diet," Schultz says. "The body is too smart for that.

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Top 5 Health Drinks For Weight Loss

People who wish to get rid of fat present in their bodies should know what exactly they should drink or eat for achieving their weight loss targets. There are many people who have lost a lot of weight by drinking various kinds of weight loss drinks. It is best to compliment your diet with different kinds of exercises. People should understand that they can achieve fast weight loss only by combining an appropriate diet with exercises. Following are top 5 health drinks for weight loss.

People who like black coffee should drink it more often as it helps in reducing weight. It offers zero calories to the body. If you wish to lose your weight then you should drink black coffee for 4 times or less every day. Do not try to drink lot of it as more of anything can cause problems. This drink helps in boosting metabolism and control mood swings.

The weight loss benefits of green tea are not hidden from many people now. People who drink green tea are less likely to put a lot of weight. This drink has a large number of antioxidants which increase the rate of metabolism in the body. This drink can boost the fat burning process in your body.

People can reduce their weight by drinking fiber drinks. These drinks help people in avoiding the habit to overeat. They keep the digestive system of people sound. By having these drinks, people feel fuller and they do not overeat. You can buy such drinks easily from the market.

Water is very important for body and it is also beneficial for weight loss. People should understand that if they wish to lose weight they need to drink more water. People should drink at least 2 glasses of ice water daily for reducing their weight. Ice water helps in increasing the rate of metabolism in the body.

In order to lose your weight, you should start drinking fruit juice. Make sure that the fruit juice you drink has no added sugar. Fruit juice offers various minerals and vitamins to the body. Fruit juice which has a lot of pulp is better for weight loss. Pulpier fruit juice offers a lot of fiber to the body which is good for weight loss. Your body will also get many nutrients by having fruit juice.

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