Thursday, January 31, 2013

Adrien Brody out and about in Hong Kong


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FDA Panel Backs New Type of Diabetes Drug

prescription bottle

Jan. 16, 2013 -- An FDA advisory panel has given its blessing to canagliflozin (Invokana) for the treatment of type 2 diabetes.

The panel voted 10 to 5 in favor of the drug’s approval, but did express concern about heart and stroke risks. The FDA is not obligated to follow the advice of its panels, but it usually does. The FDA is expected to give its decision in March.

Taken by mouth once a day, the drug could be the first in a new class of diabetes drugs called sodium-glucose cotransporter 2 (SGLT2) inhibitors. Canagliflozin works to reduce the amount of blood sugar (glucose) reabsorbed by the kidneys. This results in glucose being expelled in the urine.

Preliminary data suggest that people who take the new medication have lower glucose levels and also lose weight. Studies of the new drug are ongoing.

The drug is being developed by Johnson & Johnson subsidiary Janssen Research & Development.

Despite recommending approval of the new drug, panel members expressed concerns about risks of heart disease and stroke. But data on studies evaluating this risk were insufficient.

They also expressed concerns about the use and safety of this drug in people with kidney disease. As such, some panel members recommended that people with kidney damage do not use this  drug if it is approved.

In January 2012, the FDA voted against another SGLT2 inhibitor, dapagliflozin, due to concerns about a cancer risk. This drug was approved in the European Union in November 2012. There is no cancer risk seen with canagliflozin.


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Dappy found guilty of assault and affray


N-Dubz star Costadinos "Dappy" Contostavlos has been found guilty of assault and affray in court today.

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Bradley Cooper at a screening of Silver Linings Playbook in Spain


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'Xtreme Eating Awards': And the Winner Is?

Jan. 16, 2013 -- The Center for Science in the Public Interest (CSPI) has announced its seventh annual Xtreme Eating Awards, and as usual, there are some eye-popping, belt-busting, and artery-clogging stats behind these oversized restaurant meals.

Some of this year’s biggest offenders are dishes even savvy diners might not suspect:

Despite healthy ingredients like mushrooms, arugula, and tomatoes, the Bistro Shrimp Pasta from the Cheesecake Factory has more calories (3,120) than any other entree on the menu. It even has more calories than the cheesecake. Loads of butter and cream in the sauce deliver 89 grams of saturated fat.There are more than 1,460 calories and 22 teaspoons of added sugar swirled into a large Peanut Power Plus Grape Smoothie from Smoothie King.The Cheesecake Factory makes a second appearance in this year’s awards with the Crispy Chicken Costoletta: a single dish that has more calories and fat than an entire bucket of KFC Original Recipe Fried Chicken. A bucket of 12 pieces has 2,550 calories. Chicken Costoletta tips the scales at 2,610 calories.

Other orders that could quickly send you up a dress size:

The Bacon Cheddar Double from Johnny Rockets has 1,770 calories, more than three McDonald’s Quarter Pounders with cheese. It also packs 50 grams of saturated fat and 2,380 milligrams of sodium.Also from Johnny Rockets, the Big Apple Shake, which mixes a piece of apple pie into a vanilla milkshake, has 1,140 calories, 37 grams of saturated fat, and 13 teaspoons of added sugar.With 2,710 calories, 45 grams of saturated fat, and 3,700 milligrams of sodium, the Veal Porterhouse with red potatoes from Maggiano’s Little Italy is like eating four Pizza Hut Personal Pan Pepperoni Pizzas.Country-Fried Steak & Eggs from IHOP packs almost a full day's worth of calories and fat right into breakfast -- 1,760 calories.

“Years ago, if you went out and splurged, you ruined your diet for the day. With items like this, you’re ruining your diet for the week in some cases,” says Jayne Hurley, RD, a nutritionist at the CSPI who worked on the list.

“A lot of these chain restaurants, to be fair, do have a healthy or light section on their menu,” Hurley says, “but it’s like less than a handful of items. And then they’ve got pages of these 2,000- and 3,000-calorie monster meals.”

“Clearly, restaurants need to work on doing a menu makeover and slenderizing some of these,” she says.

The National Restaurant Association says that’s already happening. According to its 2013 industry forecast, over 85% of adults say there are more healthy options at restaurants than there were two years ago.


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Wednesday, January 30, 2013

Kate Moss and Jamie Hince celebrate her birthday


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Mollie King on the street in NY


Mollie King wears a camel-coloured coat and a fur Cossack hat on the street in New York- vote on celebrity fashion, style and red carpet looks in GLAMOUR.COM’s Dos and Don’ts

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