Tumors with a key mutation seemed unaffected by daily use of the drug, study found
By Robert Preidt
HealthDay Reporter
TUESDAY, June 25 (HealthDay News) -- Numerous studies have found that daily low-dose aspirin might help shield against colon cancer. But new research suggests that gene mutations found in different colon tumors may influence that relationship.
This study of data from more than 127,000 people in the Nurses' Health Study and the Health Professionals Follow-Up Study in the United States found that the benefits of aspirin used were affected by mutation of a gene called BRAF.
Specifically, regular aspirin use was associated with a lower risk of colorectal cancers characterized by the "typical" form of BRAF, but not with the risk of colon cancers with mutated forms of BRAF.
These findings suggest that BRAF-mutant colon tumor cells may be less sensitive to the effects of aspirin, according to the study in the June 26 issue of the Journal of the American Medical Association.
The researchers also found that taking a higher number of aspirin tablets a week -- more than 14 tablets -- was associated with a lower risk of colorectal cancer with typical BRAF, but this was not seen with BRAF-mutated cancers, according to a journal news release.
The research was led by Reiko Nishihara of the Dana-Farber Cancer Institute in Boston.
Importantly, regular aspirin use after a diagnosis of either type of colorectal cancer did not improve patients' survival, the team said.
"This suggests that the potential protective effect of aspirin may differ by BRAF status in the early phase of tumor evolution before clinical detection but not during later phases of tumor progression," the study authors wrote.
May 10, 2013 -- Taking antibiotics could relieve symptoms of chronic lower back pain for up to 40% of people, according to a new study.
Danish researchers say they've found a link between many cases of back pain and infection from bacteria.
Some experts have questioned how many people are likely to benefit from this treatment. Others have cautioned that boosting antibiotic use in the face of growing resistance could be counterproductive and lead to more superbugs.
Back pain is a common condition, affecting about 4 out of 5 people at some point in their lives.
Recommended treatments include painkillers, hot or cold compresses, lifestyle changes, physical therapy, and keeping active. In extreme cases, when other treatments have failed, surgery may be carried out to remove part of a damaged disc.
The latest studies from the University of Southern Denmark build on previous research, which shows that between 7% and 53% of patients with herniated discs have a type of bacteria. In these patients the bacteria entered the disc at the time it was herniated, or "slipped."
In the first study of 61 patients who had spinal surgery for lower back pain, the researchers found bacteria in 46% of the slipped discs.
In a second study, the research team recruited 162 patients who had been living with low back pain for more than 6 months following a slipped disc. Half of the patients were given a 100-day course of antibiotic treatment, while the others received a placebo.
After a 1-year follow-up period, those who'd taken antibiotics were less likely to still have lower back pain and physical disability. They were also less likely to have leg pain and to have taken days off work because of their back.
The researchers estimate that about 35% to 40% of people with long-term back pain have excess fluid in the spinal vertebrae and might benefit from this type of treatment.
The findings are published in the European Spine Journal.
Media reports that antibiotics could be a cure for back pain have alarmed John O'Dowd, a consultant spinal surgeon and president of the British Society for Back Pain Research.
"Unless you've had a disc herniation ... I don't think you should be getting too excited, and I don't think this is going to be a treatment for you," O’Dowd says. "I think this is another useful building block of evidence, but I don't think it's either a cure or the answer to back pain."
Talking, texting users aren't looking out for dangers, study finds
By Randy Dotinga
HealthDay Reporter
TUESDAY, June 25 (HealthDay News) -- Pedestrians are becoming more likely to be injured while using their cellphones and an estimated 1,500 were treated in U.S. emergency rooms in 2010 as a result, a new study finds.
It's impossible to know how many of the injuries could have been avoided if pedestrians weren't using their cellphones. The study also doesn't determine whether the injuries are on the rise simply because more people are using cellphones.
Whatever the case, study author Jack Nasar said the findings show that cellphone use isn't just a danger to drivers. It's also a hazard to those who are only strolling.
"Stop walking when you're going to take a cellphone call or text. Don't do two things at once," advised Nasar, a professor of city and regional planning at Ohio State University who studies cellphones and distraction.
Nasar and colleagues previously reported that pedestrians on public streets are more likely to have close calls with cars if they are using their cellphones. In the new study, the researchers sought to understand the risk on a national level by examining a federal database of emergency room visits from 2004 to 2010.
The investigators found that the estimated number of pedestrian injuries linked to cellphones -- including those that had nothing to do with cars, such as walking into something -- varied from as low as 256 to as high as 597 between 2004 and 2007. The numbers then jumped to 1,055 in 2008, 1,113 in 2009 and 1,506 in 2010.
Deaths are not included in the study. It also doesn't break out injuries by seriousness; some injuries were minor.
The study gives details about some injuries that have been reported. In one case, a 21-year-old male suffered a sprained elbow and spinal sprain when he was hit by a car while on his phone. In another, a 28-year-old man walked into a pole and lacerated his brow. And a 14-year-old boy fell several feet off a bridge into a ditch, bruising his chest.
People under 31 were among those most likely to be hurt while walking and using a cellphone, with those aged 21 to 25 sustaining the most injuries, followed by 16- to 20-year-olds. Men were slightly more likely (53 percent) than women to be pedestrian victims.
The estimated numbers of injuries to pedestrians on cellphones were roughly equal to those of drivers who were on cellphones. Even at the height in 2010, however, the estimated injuries accounted for fewer than 4 percent of all estimated injuries to pedestrians.
Nasar said the estimates in the study may greatly underestimate the risk of cellphone use to pedestrians.
John Lee, a professor with the department of industrial and systems engineering at the University of Wisconsin-Madison who studies distracted driving, said the new research has weaknesses. "It could be that cellphones are associated with a greater number of injuries simply because it is more likely that people are using a phone at the time," he said, "and it is hard to know if cellphone use actually causes these mishaps or is even associated with them."
Also in attendance at the ASMALLWORLD Relaunch Weekend in Morocco, was gap yah student Olivia Wilde. Oh, sorry, wait: we meant Hollywood star Olivia Wilde. So easy to confuse the two in this image. Hmm. Anyhoo. The actress was seen to be letting loose at the bash as she channelled her inner Britney Spears and walked around the party with a snake draped over her shouders.
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Track your way to weight loss success Manage your family's vaccinations Join the conversation See more benefits Sign Up Why WebMD? My WebMD Show Menu My Tools My WebMD Pages My Account Sign Out FacebookTwitterPinterest WebMD Home Heart Health Center Atrial Fibrillation and Stroke Email a Friend Print Article if (pf_param == "true") {printElements();} Atrial Fibrillation and Stroke Next Article: Skip to Article Content Atrial Fibrillation and Stroke AFib Treatment Facts on AFib treatments, including blood thinners to prevent clots. Stroke Prevention Procedures to help control or stop AFib. Get the Facts on AFib Learn the basics of heart rhythm disorders. AFib: Causes and Risks Find out who's at highest risk for AFib, and why. How AFib Is Diagnosed Your practical guide to tests used to diagnose atrial fibrillation. AFib: Medical Care Getting the most from your medicine and your health care team. 6 Medical Symptoms Never to Ignore Is that medical symptom life-threatening? Facts you should know. Atrial Fibrillation Symptoms Symptoms of atrial fibrillation explained in easy-to-understand terms. The Warning Signs of Stroke How to recognize the signs and symptoms of stroke. Stroke: Who's at Risk? Stay proactive and informed. Find out who's at risk for having a stroke. AFib: Your Healthy Lifestyle How healthy eating, exercise, and relaxation help you feel your best with AFib. False 6 Serious Medical Symptoms Some medical symptoms are warnings that you need immediate care. Learn to recognize them. WebMD Feature By Katherine Kam Reviewed By Brunilda Nazario, MD
That new symptom is troubling: the inexplicable swelling in your calf or the blood in your urine. Could it be serious or even life-threatening?
"Your body flashes signals -- symptoms and signs -- that warn you of potential problems," say Neil Shulman, MD, Jack Birge, MD, and Joon Ahn, MD. The three Georgia-based doctors are the authors of the book Your Body's Red Light Warning Signals.
Fortunately, many symptoms turn out not to be serious. For example, the majority of headaches stem from stress, eyestrain, lack of sleep, dehydration, caffeine withdrawal, and other mundane causes.
But a sudden, agonizing "thunderclap" headache -- the worst of your life -- could mean bleeding in the brain. Being able to recognize this serious symptom and calling 911 may save your life.
Here are six important flashing signals.
1. Paralysis of the arms or legs, tingling, numbness, confusion, dizziness, double vision, slurred speech, trouble finding words, or weakness, especially on one side of the face or body.
These are signs of stroke -- or a "brain attack" -- in which arteries that supply oxygen to the brain become blocked or rupture, causing brain tissue to die.
Symptoms depend on which area of the brain is involved. If a large blood vessel is blocked, a wide area may be affected, so a person may have paralysis on one side of the body and lose other functions, such as speech and understanding. If a smaller vessel is blocked, paralysis may remain limited to an arm or leg, or even the face.
If you have symptoms, call 911 right away and get to an emergency room that offers clot-busting therapy for strokes due to blocked vessels. Such treatment, which dissolves clots in blocked vessels, needs to be given within the first 3 hours after symptoms begin, but newer treatments may work within a longer time frame, says Birge, who is medical director at the Tanner Medical Center in Carrollton, Ga.
Timing is urgent; fast treatment can potentially stop brain tissue death before permanent brain injury happens. "There is a time clock ticking as to when you might totally recover," Birge tells WebMD.
2. Chest pain or discomfort; pain in the arm, jaw, or neck; breaking out in a cold sweat; extreme weakness; nausea; vomiting; feeling faint; or being short of breath.
These are signs of heart attack. If you get some of these symptoms, call 911 immediately and go to the emergency room by ambulance. Shulman and Birge also recommend that patients chew one regular, full-strength aspirin (unless they're allergic to aspirin) to help prevent damage to the heart muscle during a heart attack.
Not everyone who has a heart attack feels chest pain or pressure or a sense of indigestion. Some people, especially women, the elderly, and people with diabetes, get "painless" heart attacks, the doctors say. Being aware of "painless" heart attack signs is crucial: symptoms may include weakness, sudden dizziness, a pounding heart, shortness of breath, heavy sweating, a feeling of impending doom, nausea, and vomiting.
1 2 3 #url_reference {display: none};#url_reference { display: block; line-height: 150%; margin-bottom: 10px; }#logo_rdr img { visibility: visible; }.titleBar_rdr .titleBarMiddle_fmt { padding-top: 1.5em;} Atrial Fibrillation Atrial Fibrillation Living With AFib AFib Treatments Heart Rhythm Reset Facts on AFib AFib Risks Diagnosing AFib For Family Medical Care Serious Symptoms Signs of AFib Signs of Stroke Stroke Risk Factors Live Well With AFib // self executing function for scope (function(){ // grabs pageview id out of global scope and makes sure it exists as we need to pass it to ads in that case var pageviewId = window.s_pageview_id || ''; var iframeURLOutOfPB = '//as.webmd.com/html.ng/transactionID=220340691&tile=775164985&tug=&pug=__&site=2&affiliate=20&hcent=&scent=948&pos=113&xpg=1629&sec=&au1=1&au2=1&uri=%2fheart%2fatrial-fibrillation-stroke-11%2fserious-symptoms&artid=091e9c5e80011096&inst=0&leaf=12948&segm=0&cc=10&tmg=&bc=_i_j45_r52_&mcent=µ=&pvid=' + pageviewId; var cleanIframeURL = iframeURLOutOfPB.replace(/&/g, '&'); var ad = { adLocation:'left', adURL:cleanIframeURL, trans:'220340691', tile:'775164985', pos:'113' }; // check to make sure this seed call functionality exists, if it does, dooo it if(webmd.object.exists('webmd.ads.handleAdSeedCall')) { webmd.ads.handleAdSeedCall(ad); } })(); // self executing function for scope (function(){ // grabs pageview id out of global scope and makes sure it exists as we need to pass it to ads in that case var pageviewId = window.s_pageview_id || ''; var iframeURLOutOfPB = '//as.webmd.com/html.ng/transactionID=220340691&tile=775164985&tug=&pug=__&site=2&affiliate=20&hcent=&scent=948&pos=121&xpg=1629&sec=&au1=1&au2=1&uri=%2fheart%2fatrial-fibrillation-stroke-11%2fserious-symptoms&artid=091e9c5e80011096&inst=0&leaf=12948&segm=0&cc=10&tmg=&bc=_i_j45_r52_&mcent=µ=&pvid=' + pageviewId; var cleanIframeURL = iframeURLOutOfPB.replace(/&/g, '&'); var ad = { adLocation:'right', adURL:cleanIframeURL, trans:'220340691', tile:'775164985', pos:'121' }; // check to make sure this seed call functionality exists, if it does, dooo it if(webmd.object.exists('webmd.ads.handleAdSeedCall')) { webmd.ads.handleAdSeedCall(ad); } })(); Life With Atrial Fibrillation Tips and facts to help you live your best with atrial fibrillation. Atrial Fibrillation Poll Which atrial fibrillation symptom bothers you the most? Palpitations Shortness of breath Lightheadedness or dizziness Chest pain I don't have any symptoms View Results WebMD Video Series Atrial Fibrillation Atrial Fibrillation Discover what happens during atrial fibrillation and what your doctor can do to manage it. Spotting a Stroke Spotting a Stroke Stroke is a leading killer of women, but the risk is higher for African Americans. Learn how one survivor is increasing awareness. Health Solutions From Our Sponsors Osteoarthritis Center Diagnosed With Low T? Vaccine Questions? Back Always Aching? High Triglycerides? Child with Diabetes? Therapy for Low T Vaccines for All Ages Treating Knee Pain Depression Treatment Chronic Low Back Pain Treating Fibromyalgia Middle-of-the-Night Wakeup? Help for Joint Pain Benefits and Risks of Vaccines More From WebMD: Treating Depression|RA Basics|Ulcerative Colitis Diet|Crohn's Disease|Insomnia Myths|Low Testosterone|Managing OA Pain|HIV Myths Find us on:URAC: Accredited Health Web SiteHonCode: Health on the Net FoundationAdChoicesAbout WebMD Advertise With Us Terms of Use Privacy Policy Sponsor Policy Site Map Careers Contact UsMedscape Reference eMedicineHealth RxList Medscape MedicineNet BootsWebMD WebMD CorporateFirst Aid WebMD Magazine WebMD Health Record WebMD Mobile Newsletters Dictionary Physician Directory
If you ever work out with resistance bands (like with our 10-Minute Tone-Up) you know that they are great for strength training anywhere -- no giant machines or heavy hand weights required. Purists may say that resistance bands are fine they way they are -- why mess with something that works and make it more complicated (and way more expensive)? But if you're an adventurous home exerciser who's always looking for the next new thing, the Body LX 360 puts a cool twist on resistance training that you'll want to try for yourself.
Like many infomercial-style fitness systems, the Body LX 360 promises to help you "work smarter, not harder," by isolating specific muscle groups and helping you tone trouble spots faster. And while the package may look pretty elaborate (it comes with SEVEN DVDs!), the idea behind the whole system is pretty simple: It consists of a fold-out "board" with a cushioned seating/standing area, and various notches around the steel frame for attaching different color resistance bands. Three different colors offer varying levels of resistance, and three attachment options (hand grips, a waist belt, and an ankle strap) let you work different parts of your body.
The included DVDs focus on areas including legs, arms, shoulders, abs, and hips/butt, and you can customize the moves by adjusting the resistance level as you go.
Some of the moves I tried with the Body LX 360 felt totally weird and awkward, and some I really loved. It's cool that it folds up and is extremely portable, and that there are so many workout options available for it. The Body LX 360 is one of those devices that, when you look at it, you think "I could have made this myself for a lot less than $250" -- but then again, you know you never really would have, right?
Will you try the Body LX 360 system? Tweet us your thoughts at @amandaemac and @SELFmagazine.